OSCAR: Omics Approaches to Urological Cancer Diagnosis
Welcome to the OSCAR study page
Current screening for prostate cancer (PCa) has a high level of over-diagnosis, resulting in many men needlessly having invasive tests and arduous unnecessary treatment. There is therefore a need to identify new biomarkers, based on innovative screening approaches.
Omics is a field showing increasing promise in the identification of biological markers indicating disease. Metabolomics allows a snapshot of metabolism to be obtained and may be considered the sum of all omic approaches as it integrates transcriptomic and translational regulatory mechanisms.
This research project is a collaboration between Aberystwyth University (AU) and Betsi Cadwaladr University Health Board (BCUHB). The aim is to use a “big biology” ‘omic approach, to screen for novel metabolic changes in PCa patients, which can aid in both the diagnosis and prognosis of the disease. These metabolites could be developed into point of care tests, e.g., based on lateral flow systems.
The OSCAR Strategy
We work with patient and volunteer samples (blood and urine) and use so called "omic" approaches to work out what is in the samples. We examine genes, proteins, biochemicals and microbes to see what is different in people who have prostate cancer compared to a range of other diseases.
Meet the Team
The OSCAR team is indepted to the volunteers which are helping us improve prostate cancer detection and treatment.
Working with others around the work, we will beat it!
Watch this space..there are exciting developments soon!