Science Lab

OSCAR: Omics Approaches to Urological Cancer Diagnosis

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Current screening for prostate cancer (PCa) has a high level of over-diagnosis, resulting in many men needlessly having invasive tests and arduous unnecessary treatment. There is therefore a need to identify new biomarkers, based on innovative screening approaches.


Omics is a field showing increasing promise in the identification of biological markers indicating disease. Metabolomics allows a snapshot of metabolism to be obtained and may be considered the sum of all omic approaches as it integrates transcriptomic and translational regulatory mechanisms.


This research project is a collaboration between Aberystwyth University (AU) and Betsi Cadwaladr University Health Board (BCUHB). The aim is to use a “big biology” ‘omic approach, to screen for novel metabolic changes in PCa patients, which can aid in both the diagnosis and prognosis of the disease. These metabolites could be developed into point of care tests, e.g., based on lateral flow systems.

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Miss Tracy C. Knight

Doctoral student

Tracy went to university as a mature student gaining a BSc in Biochemistry at Aberystwyth University. She is now studying for a PhD at Aberystwyth investigating new approaches to screening for prostate cancer, employing novel genetic, metabolomic and proteomic approaches. Outside of research Tracy enjoys reading and movies, alongside spending time with family and friends.

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