Clinical Hub Aberystwyth
Your Health Matters
Publications
This page brings together peer reviewed papers, conference abstracts and preprints from Clinical Hub Aberystwyth and our collaborators, grouped by research area. Click any DOI to read the full paper.
Breast Cancer (BECA)
Zainurin, N.A.A., et al. (2026). Metabolic fingerprinting of urine reveals metabolite changes in women with breast cancer. Cancer Medicine. doi:10.1002/cam4.72018
Zainurin, N.A.A., et al. (2025). The urinary proteome differs with the presence and type of breast cancer. Journal of Proteome Research. doi:10.1021/acs.jproteome.5c00229
Laziri, N., Zainurin, N.A.A., Bambarandhage, A.U.K.H., et al. (2026). Breast cancer is linked to changes in the urinary extracellular vesicle proteome. medRxiv (preprint). doi:10.64898/2026.05.08.26352674
Bambarandhage, A.U.K.H., Zainurin, N.A.A., Laziri, N., et al. (2026). Extracellular vesicle derived urinary metabolomes show distinctive changes with breast cancer. medRxiv (preprint). doi:10.64898/2026.01.05.26343426
Respiratory, Sleep and Lung Disease
O'Rourke, S., et al. (2026). Urinary metabolomic profiling in obstructive sleep apnoea hypopnoea syndrome. Journal of Sleep Research. doi:10.1111/jsr.70271
Kramarić, T., de Araujo, R.P., Love, K., Asibey-Berko, T., Ghosh, S., Lewis, K.E., Mur, L.A.J. (2022). Systemic changes in monoacylglycerols could be an indicator of inflammation in COPD. Thorax 77 (Suppl 1), A90–A91.
O'Rourke, S., Thomas, S., Lewis, C., Bowen, S., Mur, L., Lewis, K. (2021). The effect of continuous positive airway pressure on key plasma metabolites identifying obstructive sleep apnoea hypopnoea syndrome. BMJ Open Respiratory Research 8, A6–A7. doi:10.1136/bmjresp-2021-bssconf.11
Kramarić, T., Thomas, S., Love, K., et al. (2020). Early exploratory use of omic approaches to assess metabolite changes in COPD. European Respiratory Journal 56, 322. doi:10.1183/13993003.congress-2020.322
Mansfield, B., Ho, T.R., Mudway, I., et al. (2020). Calcium sensing receptor antagonists, calcilytics, prevent activation of human dendritic and epithelial cells. European Respiratory Journal 56, 1970. doi:10.1183/13993003.congress-2020.1970
Wolffs, K.L., Mansfield, B., Bruce, R.T., et al. (2020). Calcium sensing receptor antagonism as a novel therapeutic for pulmonary fibrosis. medRxiv (preprint). doi:10.1101/2020.03.12.20034751
Paes de Araujo, R., Bertoni, N., Seneda, A.L., et al. (2019). Defining metabolic rewiring in lung squamous cell carcinoma. Metabolites 9. doi:10.3390/metabo9030047
Mansfield, B., Huang, P., Bruce, R., et al. (2019). Calcium sensing receptor antagonists (calcilytics) as a novel therapeutic for alarmin driven inflammatory lung disease. Thorax 74, A2–A3. doi:10.1136/thorax-2019-BTSabstracts2019.4
Cameron, S.J.S., Lewis, K.E., Huws, S.A., et al. (2017). A pilot study using metagenomic sequencing of the sputum microbiome suggests potential bacterial biomarkers for lung cancer. PLoS ONE 12, e0177062. doi:10.1371/journal.pone.0177062
Mur, L., Mironas, A., Paes, R., O'Shea, K., Lewis, K. (2017). Non targeted integrative multi omics approaches on sputum reveal potential diagnostic and monitoring biomarkers for respiratory diseases. European Respiratory Journal 50, PA375.
Cameron, S.J.S., Lewis, K.E., Beckmann, M., et al. (2016). The metabolomic detection of lung cancer biomarkers in sputum. Lung Cancer. View article
Veterinary Research
Scott-Baumann, J., Beckmann, M., Villarreal-Ramos, B., Rooke, D., Hewinson, G., Delahay, R.J., Mur, L.A.J. (2025). Metabolomic changes in the peripheral blood of wild trapped badgers (Meles meles) correlate with bovine tuberculosis (Mycobacterium bovis) infection status. BMC Veterinary Research. doi:10.1186/s12917-025-05144-6
Scott-Baumann, J., et al. (2022). Untargeted metabolomic analysis of thoracic blood from badgers indicate changes linked to infection with bovine tuberculosis (Mycobacterium bovis): a pilot study. Metabolomics. doi:10.1007/s11306-022-01915-6
Scott-Baumann, J.F., et al. (2022). The faecal microbiome of the wild European badger Meles meles. Current Microbiology 79, 363. doi:10.1007/s00284-022-03064-4
Scott-Baumann, J., et al. (2022). Metabotyping the Welsh population of badgers based on thoracic fluid. Metabolomics 18, 30. doi:10.1007/s11306-022-01888-6
Taylor, E.N., et al. (2022). Defining fatty acid changes linked to rumen development, weaning and growth in Holstein Friesian heifers. Metabolites 12. doi:10.3390/metabo12050374
Taylor, E.N., et al. (2022). Metabolomic changes in Mycobacterium avium subsp. paratuberculosis (MAP) challenged Holstein Friesian cattle. Metabolomics 18, 21. doi:10.1007/s11306-022-01876-w
Taylor, E.N., et al. (2022). Metabolomic changes in lactating multiparous naturally MAP infected Holstein Friesian dairy cows. Research in Veterinary Science 152, 354–363. doi:10.1016/j.rvsc.2022.09.001
Taylor, E.N., et al. (2022). Metabolomic changes in polyunsaturated fatty acids and eicosanoids. Veterinary Research 53, 68. doi:10.1186/s13567-022-01087-0
Taylor, E.N., et al. (2021). Metabolomic changes in naturally MAP infected Holstein Friesian heifers. Metabolites 11. doi:10.3390/metabo11110727
Natural Products (Airmed)
Bhowmick, S., Beckmann, M., Shen, J., Mur, L.A.J. (2022). Identification and metabolomic characterization of potent anti MRSA phloroglucinol derivatives from Dryopteris crassirhizoma Nakai (Polypodiaceae). Frontiers in Pharmacology 13, 961087. doi:10.3389/fphar.2022.961087
Adeniyi, O., Baptista, R., Bhowmick, S., Cookson, A., Nash, R.J., Winters, A., Shen, J., Mur, L.A.J. (2022). Isolation and characterisation of quercitrin as a potent anti sickle cell anaemia agent from Alchornea cordifolia. Journal of Clinical Medicine 11. doi:10.3390/jcm11082177
Baptista, R., Bhowmick, S., Shen, J.Y., Mur, L.A.J. (2021). Molecular docking suggests the targets of anti mycobacterial natural products. Molecules 26. doi:10.3390/molecules26020475
Cao, D., Sun, P., Bhowmick, S., Wei, Y.H., Guo, B., Wei, Y.H., Mur, L.A.J., Sun, Z.L. (2021). Secondary metabolites of endophytic fungi isolated from Huperzia serrata. Fitoterapia 155. doi:10.1016/j.fitote.2021.104970
Bhowmick, S., Baptista, R., Fazakerley, D., Whatley, K.E., Hoffmann, K.F., Shen, J., Mur, L.A.J. (2020). The anti mycobacterial activity of Artemisia annua L is based on deoxyartemisinin and artemisinic acid. bioRxiv (preprint). doi:10.1101/2020.10.23.352500
Crusco, A., Baptista, R., Bhowmick, S., Beckmann, M., Mur, L.A.J., Westwell, A.D., Hoffmann, K.F. (2019). The anti mycobacterial activity of a diterpenoid like molecule operates through nitrogen and amino acid starvation. Frontiers in Microbiology 10, 1444. doi:10.3389/fmicb.2019.01444
Crusco, A., Whiteland, H., Baptista, R., Forde-Thomas, J.E., Beckmann, M., Mur, L.A.J., Nash, R.J., Westwell, A.D., Hoffmann, K.F. (2019). Antischistosomal properties of sclareol and its Heck coupled derivatives: design, synthesis, biological evaluation, and untargeted metabolomics. ACS Infectious Diseases 5, 1188–1199. doi:10.1021/acsinfecdis.9b00034
Baptista, R., Fazakerley, D.M., Beckmann, M., Baillie, L., Mur, L.A.J. (2018). Untargeted metabolomics reveals a new mode of action of pretomanid (PA 824). Scientific Reports 8, 5084.
Baptista, R., Bhowmick, S., Nash, R.J., Baillie, L., Mur, L.A.J. (2018). Target discovery focused approaches to overcome bottlenecks in the exploitation of antimycobacterial natural products. Future Medicinal Chemistry 10, 811–822.